Magnesium Is essential for neuronal health
Magnesium plays an essential role in nerve transmission and neuromuscular conduction. It also functions in a protective role against excessive excitation that can lead to neuronal cell death (excitotoxicity), and has been implicated in multiple neurological disorders.
Low magnesium levels potentiate glutamatergic neurotransmission, leading to a supportive environment for excitotoxicity, which can lead to oxidative stress and neuronal cell death. Abnormal glutamatergic neurotransmission has been implicated in many neurological and psychiatric disorders including: migraine, chronic pain, epilepsy, Alzheimer’s, Parkinson’s, and stroke, in addition to depression and anxiety, which are commonly comorbid with these neurological disorders.